Excessive immune complexes can damage kidneys, but that’s generally fairly severe and shouldn’t be happening with a vaccination, more likely a bacterial or immune mediated condition. I don’t think there’s a particular increase with nephritis and regular vaccinations. I haven’t figured out how to do this easily yet. He knows this is probably excessively paranoid, but when you’re exposed to all that data all the time, it makes you worry. ![]() I know an immunologist that vaccinated his cats in the tail tip, so that if they do develop an ISS he will just amputate the tail. My reasoning being that if a patient does develop an ISS, then at least there’s a solid barrier in the scapula to hopefully prevent it going deeper, which improves the odds of removing it in only one surgery without removing ribs. I do routinely administer FIV vaccines over the right scapula though. I am aware of this risk, but I choose to do it anyway in this context. Once we had Bael living with us, who was lovely but FIV positive, the Relative Risk of Wonka contracting FIV became much higher, certainly higher than a 1 in 10,000 chance, and so he was vaccinated for FIV. The Relative Risk of my cat Wonka contracting FIV through a bite or a fight was extremely small when he was an only cat with a strictly indoor lifestyle. If we were in a rabies endemic country then you can bet your happy little backside that we would vaccinate for rabies, because the risks of potential rabies infection far exceed the risk of ISS. The risk of them developing ISS from rabies vaccination is very small, but it is higher than zero, and so we do not vaccinate for rabies. The Relative Risk of my cats, in Australia, developing rabies infection is zero. However it’s relative risk that we consider. ![]() Now, that’s not a huge risk, though the consequences of developing ISS are severe. So how much of a risk is it? Well, the last conference I went to presented data that put the odds of a cat developing ISS with annual vaccination at around 1 in 10,000 to 1 in 100,000. But the association is there.īut it is worth noting that Injection Site Sarcomas can result from any injection, as they all cause some tissue trauma. Whether it’s because these killed vaccines have different adjuvants, or whether it’s an intrinsic property of the retroviruses, I don’t know. There is also a stronger association between the retroviral vaccines (FIV and FeLV) and ISS. Whether this is because people are more diligent about their rabies vaccine, or whether it’s an adjuvant issue, I’m not in a position to speculate. Rabies vaccine seems to have a stronger association with ISS. Most cats get their kitten doses, and maybe an adult booster for the first two or three years, and then are ‘forgotten’ to bring in to he vet unless there is a problem or they’re dying. It’s also worth noting that in Australia, the general public is a bit on the slack side with bringing their cats in for annual vaccinations. ![]() It was in a 3 year old purebred cat, so he hadn’t had that many cumulative injections in his life, but he did get FIV vaccines. I’ve seen one Injection Site Sarcoma (ISS) in seven years of practice. So most of our feline vaccinations are F3, F4 and FIV. FeLV vaccines are not in common use, and are mostly used in high stress situations (eg breeding catteries) or in the face of an outbreak. ![]() Outdoor or indoor/outdoor cats often, but not always because humans are slack, get FIV vaccinations. Most cats get at least an F3 or an F4, and annual vaccination is recommended most of the time, because the herpesvirus component doesn’t seem to grant immunity for much more than 12 months. With rabies vaccines only being used for export. F3 (calicivirus, herpesvirus and panleukopenia).The vaccines for cats that are in common use here are: I practice veterinary medicine in Australia, and our vaccination protocols are a bit different to the USA and most of the rest of the world.
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